加速度计衍生的休息活动节奏和动脉样硬化心血管疾病之间的纵向关联
Lili Huang1, Yaqi Li1, Xinming Xu1
1Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai, China.
Sleep medicine
|June 20, 2024
概括
休息活动节律的破坏,以低幅度表示,显著增加了动脉样硬化心血管疾病 (ASCVD) 风险. 这一发现为在临床环境中识别容易感染ASCVD的个体提供了一种新方法.
科学领域:
- 时间生物学 时间生物学
- 心血管疾病流行病学
背景情况:
- 休息活动节奏对健康至关重要.
- 休息活动节奏与动脉样硬化心血管疾病 (ASCVD) 风险之间的联系尚不清楚.
研究的目的:
- 调查休息活动节奏与ASCVD风险之间的关联.
- 探索休息活动节奏和动脉硬标志物之间的关系.
主要方法:
- 利用了来自87,039名英国生物库参与者的7天加速计数据,没有基线ASCVD.
- 计算相对幅度 (M10-L5) 来量化节奏中断.
- 采用了考克斯的比例危险模型和线性回归来分析与ASCVD的关联,动脉硬度指数 (ASI) 和动脉内膜介质厚度 (cIMT).
主要成果:
- 在较低的相对幅度和增加的ASCVD风险之间发现了一种剂量反应关系 (HR 1.54最高与最低五分位数).
- 较低的相对幅度与较高的ASI和cIMT有显著的相关性.
- 最活跃时期 (M10) 的晚期发病时间与ASCVD风险增加有关.
结论:
- 减少休息活动节律幅度是较高ASCVD风险的重要预测因素.
- 休息活动节律幅度作为潜在的生物标志物用于识别有ASCVD风险的个体.
- 这些发现支持将节律评估纳入公共卫生和ASCVD风险分层的临床实践.
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