分析Evusheld在多发性硬化症患者的安全性和疗效
Emilie N Liu1, Marcos Real1, Jennifer H Yang2
1Department of Neurosciences, University of California, 9452 Medical Center Drive, 3E 519, La Jolla, San Diego, CA 92037, USA.
Multiple sclerosis and related disorders
|June 20, 2024
概括
蒂克萨吉维玛布和西尔加维玛布 (Evusheld) 在接受B细胞消耗疗法的多发性硬化症患者中似乎是安全的. 使用Evusheld与减少COVID-19感染有关,尽管在本研究中没有统计学意义.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 多发性硬化症 (MS) 患者接受B细胞消耗疗法可能会减少疫苗反应.
- 提克萨吉维玛和西尔加维玛 (Evusheld) 已被授权用于COVID-19暴露前预防.
- 关于Evusheld在MS患者的安全性和疗效的数据有限.
研究的目的:
- 调查Evusheld在MS患者的使用,安全性和疗效.
- 为了评估使用Evusheld的MS患者中的COVID-19感染率.
- 为了评估Evusheld在这个人群中的潜在副作用.
主要方法:
- 回顾性医疗记录审查和UCSD多发性硬化中心的前性队列研究.
- 纳入标准:MS诊断和使用B细胞耗尽疾病修饰疗法 (DMT).
- 评估Evusheld吸收,通过调查的副作用,以及COVID-19感染史.
主要成果:
- 61%的MS患者接受了Evusheld的注射;33名参与者接受了注射.
- 大多数副作用是轻微的注射部位反应或疲劳;没有报告严重的不良事件.
- 电子盾的使用与减少COVID-19感染的趋势有关 (p=0.06).
结论:
- 在DMT的MS患者中,Evusheld的使用是可行的,并且在MS患者中通常耐受良好.
- 虽然在统计学上不显著,但Evusheld的使用在减少COVID-19感染方面显示出潜在的益处.
- 研究结果为免疫功能低下的多发性硬化症患者的未来感染预防策略提供了信息.
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