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尿路SIRT2反映了2型糖尿病中的损伤

Yali Dai^1,2, Dan Li^3,4, Juan Peng^1,5

¹Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.

Kidney & blood pressure research

|June 20, 2024

概括

尿路SIRT2与2型糖尿病 (T2DM) 中的损伤有着强烈的联系. 尿中SIRT2水平升高与白蛋白尿症的严重程度和功能下降相关,这表明它有可能成为诊断标志物.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.
生物化学生物化学

背景情况:

在2型糖尿病 (T2DM) 中早期发现损伤对于预防长期并发症和改善患者的治疗结果至关重要.
虽然Sirtuin 2 (SIRT2) 与糖尿病有关,但其在糖尿病病中的作用尚不清楚.
这项研究调查了尿道SIRT2水平与T2DM中脏损伤之间的关联.

研究的目的:

评估尿中SIRT2水平与T2DM患者损伤标志物之间的相关性.
探索SIRT2可能导致糖尿病病的潜在机制.
为了确定尿液SIRT2是否可以作为albuminuria严重程度的预测指标.

主要方法:

在T2DM患者,db/db小鼠和高葡萄糖处理的HK2细胞中利用了ELISA,免疫突变测量,免疫组织化学,西部斑块和qPCR.
将163名T2DM患者根据尿白蛋白/肌素比率 (UACR) 分类为三组.
雇佣斯皮尔曼相关性和后勤回归分析,以评估尿液SIRT2/肌素比率 (USCR) 和损伤生物标志物之间的关系.

主要成果:

较高的USCR水平与增加的UACR,UαCR,UβCR,URCR正相关,与估计的淋巴细胞过率 (eGFR) 负相关.
在对混杂因素进行调整后,USCR被确定为T2DM患者中白蛋白尿症严重程度的显著风险因素.
在db/db小鼠脏和高葡萄糖处理的细胞中,SIRT2蛋白水平增加,通过MAPK信号传递促进促炎因素 (TNF-α,IL-6).

结论:

尿中SIRT2水平与EGFR,管损伤和T2DM中的白尿密切相关.
尿路SIRT2是全面评估2型糖尿病损伤的潜在生物标志物.
SIRT2可能在高葡萄糖诱导的炎和损伤中发挥作用.

关键词:

糖尿病脏疾病糖尿病脏疾病脏生物标志物是脏的生物标志物.在Sirtuin2中,我们可以使用管道损伤的损伤

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