诺莫图谱用于估计患有末期脏疾病,接受腹腔透析的患者患慢性病相关的风险:模型开发和验证研究
Wen Gu1,2, Ming Zhang3, Changna Liang4
1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, desaix@stu.xjtu.edu.cn.
Blood purification
|June 20, 2024
概括
一种新的诺莫格拉姆模型有助于估计慢性病相关的 (CKD-aP) 的风险,用于腹腔透析 (PD) 的患者. 这种工具有助于临床医生为个性化CKD-aP治疗策略做出明智的决定.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 皮肤病学 皮肤病学
- 医疗信息学 医疗信息学
背景情况:
- 慢性病相关的 (CKD-aP) 是患有末期病 (ESRD) 的腹腔透析 (PD) 患者常见且具有挑战性的并发症.
- 由于CKD-aP的多样性病原体,需要有效的工具来分层风险和个性化管理.
研究的目的:
- 开发和验证一种名谱模型,用于预测经过PD的ESRD患者中CKD-aP的风险.
- 确定在这个患者群体中导致CKD-aP的关键因素.
主要方法:
- 在2021年至2023年期间接受PD的487名患者的回顾性分析.
- 使用多变量逻辑回归和最小绝对收缩和选择运算符 (LASSO) 回归开发名录.
- 使用引导和单独的验证队列进行内部和外部验证,通过Harrell的C指数和校准曲线评估辨别能力.
主要成果:
- 开发了一种纳米图,包括年龄,白血素-6,血红蛋白,余尿量和脏Kt/V.
- 该模型在发展队列中表现出良好的区分能力,C指数为0.733,并得到了外部验证 (C指数:0.706).
- 校准曲线和决策曲线分析证实了模型的准确性和临床有用性.
结论:
- 开发的诺米图为评估PD患者中CKD-aP风险提供了有价值的工具.
- 该模型可以支持临床决策,并指导选择基于证据的CKD-aP治疗干预措施.
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