老年人对间歇性禁食和健康生活饮食的大脑反应
Dimitrios Kapogiannis1, Apostolos Manolopoulos2, Roger Mullins3
1Intramural Research Program, Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Cell metabolism
|June 20, 2024
概括
两种饮食,5:2间歇性禁食和健康的生活方式,改善了胰岛素抵抗的老年人的大脑健康. 这两种饮食都增强了认知功能和代谢生物标志物,间歇性禁食在某些领域显示出更大的益处.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 代谢障碍,如胰岛素抵抗,与老年人的认知能力下降有关.
- 正在探索饮食干预措施,以促进大脑健康并减轻与衰老相关的认知变化.
研究的目的:
- 为了比较5:2间歇性禁食和健康生活饮食对具有胰岛素耐药性的认知完整的老年人大脑健康的影响.
- 研究这些饮食对认知功能,大脑衰老生物标志物和代谢健康的影响.
主要方法:
- 一项为期8周的随机临床试验,涉及40名具有胰岛素耐药性的认知完整的老年人.
- 使用磁共振成像 (MRI) 和磁共振光谱 (MRS) 评估大脑健康,并进行认知测试和血液/脑脊液生物标志物分析.
主要成果:
- 这两种饮食都改善了胰岛素信号生物标志物,减少了大脑年龄差距估计,并降低了大脑葡萄糖水平.
- 认知功能,包括执行功能和记忆力,在两种饮食中都出现了改善,间歇性禁食在特定的认知措施中显示出了优势.
- 探索性分析表明,性别,体重指数和特定的遗传因素 (apolipoprotein E和SLC16A7) 可能会影响饮食反应.
结论:
- 饮食干预措施,包括间歇性禁食和健康的生活饮食,可以对胰岛素耐药的老年人脑部健康和认知功能产生积极影响.
- 这些发现为评估优化大脑健康的饮食策略提供了一个框架,并要求进一步研究间歇性禁食和连续饮食的长期影响.
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