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在红耳滑鼠 (Trachemys scripta elegans) 中,皮下给予阿米卡会产生长时间可检测的血度,而没有生物化学证据表明功能受损

Kara Hiebert¹, Heather Knych², Shawna Hawkins¹

¹Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.

American journal of veterinary research

|June 20, 2024

概括

皮下给红耳滑鼠的阿米卡辛在5毫克/公斤剂量下持续至少三周. 没有观察到生物化学参数的显著变化,但建议在重复剂量时谨慎使用.

科学领域:

兽医药理学兽医药理学
类学类学类学类学
水生动物医学水生动物医学

背景情况:

阿米卡辛是一种用于兽医的氨基糖化物抗生素.
对于爬行动物,特别是红耳滑动动物 (Trachemys scripta elegans) 中的阿米卡的药理动力学数据有限.
了解阿米卡辛的血度和潜在的毒性对于有效治疗这种物种至关重要.

研究的目的:

为了确定皮下 (SC) 两剂 (5和10毫克/公斤) 给红耳滑鼠后的阿米卡的血度.
评估并发的血生物化学参数,以评估潜在的毒性.
在这种爬行动物物种中建立阿米卡辛药理学试点数据.

主要方法:

八只成年红耳滑动动物在目标剂量为5毫克/公斤和10毫克/公斤的目标剂量中服用了阿米卡辛SC,并有3周的洗期.
在施用后的多个时间点 (0,24,48,72,96小时) 收集了血液样本.
使用LC-MS/MS测量血氨酸度,并在特定时间间隔进行生物化学分析.

主要成果:

在24小时内,阿米卡辛度的平均峰值为17.5±2.32μg/mL (5 mg/kg) 和23.6±2.92μg/mL (10 mg/kg).
在SC剂量为5mg/kg (平均1.04±0.22μg/mL) 后,阿米卡辛至少在3周内仍可检测.
在任何剂量后,也没有观察到血生物化学参数的临床相关变化.

结论:

5毫克/公斤的皮下阿米卡辛在红耳滑动动物中至少持续3周的可检测水平,这是一个新的发现.
没有任何剂量诱导的生化变化表明毒性.
需要进一步的研究来表征累积的药理动力学和毒性值,在这种物种中重复服用阿米卡辛.

关键词:

这种植物是Trachemys scripta elegans.这就是阿米卡辛.药物动力学药物动力学红耳滑动乌红耳滑动乌滑动是一种滑动.

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