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Updated: Jun 23, 2025

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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双域融合改善了Bst DNA聚合酶的逆转录酶活性和抑制剂耐受性

Rong Xiang1, Guang-Yi Liu2, Yi Hou3

  • 1School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.

International journal of biological macromolecules
|June 20, 2024
PubMed
概括

研究人员通过将BstDNA聚合酶与DNA结合和疏水性蛋白质融合,设计了一种新奇的仿真DNA聚合酶HpStBL. 这种增强的聚合酶显示出对非洲猪瘟病毒和SARS-CoV-2检测的卓越抑制剂耐受性和活性.

关键词:
Bst DNA 聚合酶是一种抑制剂的耐受性 抑制剂的耐受性循环介导的同热放大 (LAMP)分子修饰是一种分子修饰.逆转录酶活动的反转录酶.

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