局部皮质类固醇治疗疹和疹:随机试验的系统综述和贝叶斯元分析
Alexandro W L Chu1, Daniel G Rayner2, Xiajing Chu3
1Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.
概括
局部用皮质类固醇可能会减少疹中的小麦粉大小,但对有不确定的好处. 副作用与安慰剂类似,这表明对这种常见的皮肤疾病要谨慎使用.
科学领域:
- 皮肤病学 皮肤病学
- 临床药理学 临床药理学
- 基于证据的医学基于证据的医学.
背景情况:
- 局部皮质类固醇经常被处方用于疹症状缓解.
- 当地皮质类固醇对疹的精确疗效和安全性仍然不完全理解.
研究的目的:
- 系统地评估局部皮质类固醇在治疗疹时的益处和危害.
- 综合了随机对照试验 (RCT) 对局部皮质类固醇与安慰剂用于管理的证据.
主要方法:
- 进行了RCT的系统审查和元分析,比较局部皮质类固醇与的安慰剂.
- 搜索的主要数据库 (MEDLINE,EMBASE,CENTRAL) 至2024年3月.
- 使用GRADE标准评估偏见风险和证据确定性.
主要成果:
- 分析了涉及379名参与者的19个RCT.
- 局部用皮质类固醇显示可能减少小麦粉大小 (确定性低),但对的严重程度有不确定的影响 (确定性非常低).
- 在局部皮质类固醇和安慰剂 (高确定性) 之间,整体不良事件是可比的.
结论:
- 局部用皮质类固醇可以减少疹患者的小麦粉大小,对不良事件的影响最小.
- 减少的证据非常不确定,需要进一步的研究.
- 建议进行大规模的RCT,以澄清局部皮质类固醇在最佳疹治疗中的作用.
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