默认模式网络的功能连接在第一期药物素朴的患有严重抑郁症的患者中
Hui Qiu1, Lianqing Zhang2, Yingxue Gao2
1Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China; Department of Radiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Journal of affective disorders
|June 20, 2024
概括
大型抑郁症 (MDD) 与改变的默认模式网络 (DMN) 功能连接有关. 早期的MDD患者显示DMN连接性增加,与症状严重程度和认知功能相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 默认模式网络 (DMN) 的变化与严重抑郁症 (MDD) 有关.
- 仍然需要对MDD中的DMN功能连接 (FC) 改变进行强有力的,重复的研究结果.
- 在早期MDD中了解DMN FC可以澄清疾病的病理生理学.
研究的目的:
- 调查在早期,药物先验重度抑郁症 (MDD) 患者的默认模式网络 (DMN) 和其子系统中的功能连接 (FC) 改变.
- 探索已识别的FC变化与MDD的临床特征之间的关系.
主要方法:
- 招募了115名未曾服用过药物的MDD患者和137名健康对照 (HCs).
- 在DMN及其子系统内,以及DMN子系统和整个大脑之间,比较FC.
- 与临床特征相关的已识别的FC变化.
主要成果:
- 患有MDD的患者在DMN,背部DMN和中间DMN内显著增加了FC.
- 在DMN子系统和其他大脑网络之间观察到明显的FC模式.
- 核心/背部DMN和其他与抑郁症状严重程度相关的网络之间的增加FC;与记忆性能相关的中间DMN连接.
结论:
- 早期的MDD的特点是明显的DMN和FC子系统的改变.
- 这些变化与疾病严重程度和认知障碍有关,表明临床相关性.
- 限制包括由于左侧化ROI分析和概括性问题而可能错过的不对称FC.
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