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过度维生素D与不良的牙科植入物结果相关:一项回顾性病例控制研究
Yu-Chi Cheng1, Laura Murcko2, Ernesto B Benalcazar-Jalkh3
1School of Dental Medicine, Harvard University, Boston, MA, USA.
Journal of dentistry
|June 20, 2024
概括
高水平的维生素D (维生素D过高症) 显著增加了牙植入失败和骨损失的风险,特别是在部. 这一发现突出了植入物并发症的新风险因素.
科学领域:
- 口腔和牙面部外科手术
- 内分泌学 在内分泌学.
- 生物材料科学 生物材料科学
背景情况:
- 牙植入成功受到各种患者因素的影响.
- 植入周骨水平和植入存活率是关键的结果指标.
- 维生素D在骨代谢中的作用已被证实,但其对牙植入物的具体影响不太清楚.
研究的目的:
- 调查维生素D水平与牙科植入物成功之间的关联.
- 确定维生素D状态与植入物周围边缘骨水平之间的相关性.
- 评估与维生素D水平相关的周植入疾病和植入失败的风险.
主要方法:
- 追溯病例控制研究,比较患有植入周疾病的患者和健康对照.
- 在73名拥有291个牙科植入物的患者中分析了血液中的25...OH) D水平.
- 统计分析包括费舍尔的精确测试,卡普兰-梅尔生存分析和曼-惠特尼U测试.
主要成果:
- 患有高维生素 D (25(OH) D>70 ng/mL) 的患者患植入物失败或严重骨质损失的风险增加了21.1倍.
- 在19年后的植入物存活概率是超维生素D组的73.7%,而中级维生素D组的95%.
- 上部的植入物比下部的植入物更受到D型维生素过高的不利影响.
结论:
- 血中25(OH) D水平升高与牙科植入物不良结果有显著的相关性.
- 过度维生素D似乎是一个新的植入物失败和围植入物骨损失的危险因素.
- 需要进一步的研究,以了解超维生素D对牙植入物的负面影响背后的机制.
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