漏肠导致慢性阻塞性肺部疾病的男性患者的姿势失衡
Rizwan Qaisar1, Shah Hussain2, Asima Karim3
1Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates; Space Medicine Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; Cardiovascular Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
血 zonulin 显示的肠道透性增加与慢性阻塞性肺病 (COPD) 患者的姿势平衡和身体功能不佳有关,这表明其是一种潜在的治疗标.
科学领域:
- 肺部医学 肺部医学
- 胃肠病学 胃肠病学
- 老年病的医生 老年病的医生
背景情况:
- 慢性阻塞性肺病 (COPD) 患者通常会经历姿势平衡受损.
- 与COPD相关的姿势不稳定性增加的肠道透性 (漏肠) 的作用目前尚不清楚.
研究的目的:
- 为了研究血佐努林 (一种漏肠的标志物) 与COPD患者的姿势平衡之间的关联.
- 在COPD相关的姿势不平衡中探索漏肠,炎症和氧化应激之间的潜在机械联系.
主要方法:
- 血佐努林,C-反应蛋白 (CRP) 和8-异质被测量在对照组和COPD患者中.
- 用短时间的体力表现电池来评估姿势平衡.
- 还评估了手握强度 (HGS) 和步行速度.
主要成果:
- 与对照组相比,COPD患者的血 zonulin,CRP和8-isoprostanes 含量较高,平衡,HGS 和步行速度较低.
- 这些差异在中度至重度的COPD中更加明显.
- 血佐努林水平与平衡不良,HGS减少和步行速度减慢有显著的相关性.
结论:
- 血佐努林可以作为一个有价值的生物标志物来评估COPD的姿势失衡.
- 针对肠道透性可能是一个治疗策略,以提高COPD患者的姿势控制.
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