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在2型糖尿病中探索肠道微生物组调节和血压之间的关系:一个总体审查
Ehsan Amini-Salehi1, Abinash Mahapatro2, Rohan Reddy Korsapati3
1Guilan University of Medical Sciences, Rasht, Iran; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
概括
调节肠道微生物组显著影响2型糖尿病 (T2DM) 患者的透静血压. 然而,对缩血压的影响在统计学上并不显著,这表明要谨慎地解释研究结果.
科学领域:
- 微生物组研究的研究.
- 心血管健康的心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 2型糖尿病 (T2DM) 是一个全球性流行病.
- 肠道微生物群影响许多健康方面,包括血压调节.
- 了解肠道微生物组调制在T2DM管理中的作用至关重要.
研究的目的:
- 对T2DM患者肠道微生物组调节和血压的元分析进行总体审查.
- 巩固现有的关于肠道微生物干预措施对静缩和静缩血压影响的证据.
- 评估肠道微生物组调节对T2DM中血压控制的整体影响.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中的系统文献搜索 (开始至2023年7月).
- 包括6个符合PRISMA指南的元分析.
- 使用AMSTAR2和GRADE进行质量评估;通过综合元分析 (CMA) 进行统计分析.
主要成果:
- 在肠道微生物调节和透气血压之间发现了统计学意义上的关联 (SMD: -0.133,P=0.002).
- 没有观察到肠道微生物调节对缩血压有统计学意义的影响 (SMD: -0.077,P=0.078).
- 观察到对透气血压的影响虽然显著,但临床意义可能很小.
结论:
- 肠道微生物组调节在T2DM患者中显著影响透支血压.
- 没有检测到对缩血压的显著影响.
- 由于临床意义较低,人群多样化以及研究中的干预措施多样化,建议谨慎使用.
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