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Updated: Jun 23, 2025

Peptide-based Identification of Functional Motifs and their Binding Partners
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一个非B型DNA结合的二相通道改变了细胞功能

Raj Paul1, Debasish Dutta1, Titas Kumar Mukhopadhyay1

  • 1School of Chemical Sciences, Indian Association for the Cultivation of Science, Kolkata, 700032, India.

Nature communications
|June 20, 2024
PubMed
概括

一种基于 thiazole 的新型仿真体,TBP2,在细胞膜中形成离子通道,稳定 G-四重复 DNA 结构. 这一过程提升了细胞内阴离子,通过G-四重复稳定导致癌细胞死亡.

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