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通过预期-最大化分析病毒样粒子的原子力显微镜图像

Rachel A McCormick1, Nicole M Ralbovsky2, William Gilbraith1

  • 1Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.

NPJ vaccines
|June 20, 2024
PubMed
概括

使用原子力显微镜 (AFM) 分析病毒样颗粒 (VLPs) 的弹性,可以揭示这些疫苗候选物是如何变化的. 高斯混合模型 (GMM) 确定了不同的VLP状态,表明了逐步的形态变化.

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相关概念视频

Atomic Force Microscopy01:08

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
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