在患有血管免疫发育性T细胞淋巴瘤的患者中,带有史托里形纤维化的管间性炎
Haruka Fukuda1,2, Mineaki Kitamura3,4, Atsushi Sawase1,2
1Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
CEN case reports
|June 20, 2024
概括
这项案例研究突出了一个患有血管免疫芽细胞T细胞淋巴瘤 (AITL) 的患者,他还患有IgG4相关脏疾病 (IgG4-RKD). 对AITL的治疗改善了功能,这表明两种疾病之间存在联系.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 血管免疫原性T细胞淋巴瘤 (AITL) 是一种罕见的T细胞淋巴瘤.
- 带有史托里形纤维化管间性炎是一种脏疾病,可能与IgG4相关的疾病有关.
- 同时发生的AITL和IgG4相关病 (IgG4-RKD) 难以诊断.
研究的目的:
- 呈现一种与IgG4-RKD共存的AITL病例.
- 探索诊断挑战和潜在的机制,这些条件连接.
- 报告治疗结果和功能改善.
主要方法:
- 一个76岁的男性患者的病例报告.
- 诊断程序包括淋巴结活检用于AITL诊断和脏活检用于IgG4-RKD评估.
- 免疫组织化学被用来识别IgG4阳性血细胞.
- 治疗涉及AITL的THPCOP化疗.
主要成果:
- 这位患者出现了淋巴腺病,多克隆性高血糖球蛋白血症和功能障碍.
- 淋巴结活检证实AITL;脏活检显示IgG4阳性血细胞和史托里形纤维化,表明IgG4-RKD.
- 血清IgG4水平显著升高.
- 在THPCOP治疗AITL后,功能得到改善.
结论:
- 毛囊辅助T细胞的参与可能在AITL和脏管间病变中至关重要.
- 成功治疗AITL导致功能改善,强调了这些疾病的相互联系.
- 这一案例强调了在患有AITL和功能障碍的患者中考虑IgG4-RKD的重要性.
相关概念视频
Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...


