使用深度学习对正常和异常细胞分裂进行自动分类
Pablo Delgado-Rodriguez1, Rodrigo Morales Sánchez1, Elouan Rouméas-Noël2
1Universidad Carlos III de Madrid, Leganes, Spain.
Scientific reports
|June 20, 2024
概括
这项研究引入了一种自动的线粒分裂分类器,以区分正常与异常的细胞分裂,由DNA损伤引起. 深度学习模型实现了高精度,有助于分析基因组应激对细胞群的影响.
科学领域:
- 细胞生物学 细胞生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 细胞细分和跟踪方法正在进步,但与DNA损伤引起的细胞分裂等异常事件作斗争.
- 辐射或药物引起的基因组压力导致细胞行为不规则,需要专门的分析工具.
研究的目的:
- 开发一种自动分类器,用于将线粒分裂归类为正常或异常.
- 在不同水平的辐射诱导的基因组应激下分析细胞周期的发展.
主要方法:
- 利用深度学习架构,特别是一个ResNet50骨干与长短期记忆 (LSTM) 层.
- 训练并评估了暴露于辐射的细胞群的线粒分裂图像序列上的分类器.
主要成果:
- 开发的分类器实现了0.93 ± 0.06.06的高平均F1分数.
- 带有LSTM网络的ResNet50在分化事件的分类方面表现出卓越的性能.
结论:
- 为检测基因组应激下异常细胞分裂而创建了一种有效的自动分裂分类器.
- 未来的工作包括将这种分类器与细胞跟踪集成为分谱树的构建,以研究基因组应激后的人口动态.
相关概念视频
02:13Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
02:13Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...