在具有多个输入的网络中的恒温.
João Luiz de Oliveira Madeira1, Fernando Antoneli2
1Department of Mathematical Sciences, University of Bath, Bath, BA2 7AY, UK. jldom20@bath.ac.uk.
Journal of mathematical biology
|June 20, 2024
概括
这项研究对复杂系统中无限小的恒常状态的网络拓进行了分类. 三个核心机制产生稳态子网络,为理解多输入生物网络的适应提供了基础.
科学领域:
- 系统生物学 系统生物学
- 网络动态 网络动态
- 控制理论 控制理论
背景情况:
- 恒温,或适应,对于系统来说至关重要,以保持稳定的输出来应对干扰.
- 之前的研究重点是简单的,单个输入系统,限制了对复杂网络适应的理解.
研究的目的:
- 在复杂的多输入网络中,分类所有允许无限微小恒温的网络拓.
- 确定驱动复杂系统中的恒常状态的基本机制.
- 建立一个拓框架,以了解多输入网络的适应.
主要方法:
- 开发了一个适用于复杂网络架构的"无限微小的恒常状态"的框架.
- 在不假定特定组件相互作用或方程形式的情况下分析了网络拓.
- 根据它们产生恒温的能力来分类网络结构.
主要成果:
- 确定了产生无限小的平衡的三个基本机制.
- 从这些机制中产生的定义的"恒常状态子网络".
- 展示了复杂的网络可以分解成这些子网络,分类"恒常状态类型".
- 在多输入系统中发现"恒温模式相互作用".
结论:
- 这三种已识别的机制及其相关的子网络构成了复杂网络中恒温的通用拓基础.
- 这种分类促进了对多输入生物系统适应的理解,以和酸盐共同调节为例.
- 恒温模式相互作用的概念为复杂系统动态提供了新的见解.
相关概念视频
Multi-input and Multi-variable systems
106
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence...
In the absence...
106
Positive and Negative Feedback Loops
18.9K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires maintaining an internal dynamic equilibrium:
18.9K
What is Homeostasis?
37.2K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
37.2K
Control Systems
1.1K
Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
At the heart...
1.1K
Cell Signaling Feedback Loops
6.3K
Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
6.3K
Signal and System
644
A signal x(t) is a set of data or a time function representing a variable of interest. Signals typically convey information about a phenomenon, such as atmospheric temperature, humidity, human voice, television images, a dog's bark, or birdsongs. More generally, a signal can be a function of more than one independent variable. For instance, images depend on horizontal and vertical positions and can be regarded as two-dimensional signals. However, this text will focus on one-dimensional...
644


