甲状腺功能低下症和类风湿性关节炎之间的因果关系,但不是甲状腺功能过高:来自门德尔随机化研究的证据
Mingyi Yang1, Yani Su1, Ke Xu1
1Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, 710054, Xi'an, Shaanxi, China.
Wiener klinische Wochenschrift
|June 20, 2024
概括
甲状腺功能低下症与类风湿性关节炎 (RA) 有遗传联系,但甲状腺功能过高症没有. 这表明甲状腺功能低下可能是RA的危险因素,需要临床关注.
科学领域:
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
- 遗传学 是一个遗传学.
背景情况:
- 甲状腺功能障碍,包括甲状腺功能障碍和甲状腺功能障碍,影响全球众多个体.
- 类风湿性关节炎 (RA) 是一种具有显著发病率的慢性自身免疫性疾病.
- 甲状腺疾病和RA之间的潜在因果关系在遗传层面上仍然不完全理解.
研究的目的:
- 调查甲状腺功能障碍,甲状腺功能障碍和类风湿性关节炎 (RA) 之间的遗传层面的因果关系.
主要方法:
- 利用来自IEU OpenGWAS数据库的甲状腺功能过高,甲状腺功能低下和RA的全基因组关联研究 (GWAS) 总结数据.
- 使用测试和验证队列进行了两样本的门德尔随机化 (MR) 分析.
- 评估了异质性,水平性,异常值的MR结果,并进行了敏感性分析,包括Leave-one-out和MR-RAPS.
主要成果:
- 甲状腺功能低下症与RA显著呈阳性遗传因果关系 (P < 0.001).
- 甲状腺功能障碍症与RA没有显著的遗传因果关系 (P = 0.702).
- MR 分析证实没有异质性,水平性或异常值的证据,在敏感性分析中得到了强有力的发现.
结论:
- 甲状腺功能低下症因果关系与风湿性关节炎的风险增加有关.
- 甲状腺功能障碍与类风湿性关节炎没有因果关系.
- 甲状腺功能低下症可能是RA的临床风险因素,需要进一步调查和对患者管理的注意.
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