血清尿酸变异与神经成像指标和认知衰退的关联:基于人口的队列研究
Han Lv1, Jing Sun2, Tong Zhang3
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. chrislvhan@126.com.
BMC medicine
|June 20, 2024
概括
血清尿酸 (SUA) 水平的长期波动会对大脑健康产生负面影响,导致白质量减少和认知能力下降. 保持稳定的SUA水平对于保持大脑健康和预防认知障碍至关重要.
科学领域:
- 神经学 神经学
- 代谢健康 代谢健康
- 神经成像是一种神经成像.
背景情况:
- 血清尿酸 (SUA) 变化与大脑健康之间的联系尚不清楚.
- 这项研究调查了长期SUA波动与大脑健康的神经成像标志物以及认知功能之间的关联.
研究的目的:
- 为了检查血清尿酸 (SUA) 水平和神经成像指标的个体内变异性之间的关系.
- 评估SUA变异性与认知功能的关联.
- 探索SUA-认知关系中神经成像标记物的潜在调解.
主要方法:
- 从基于社区的队列中招募了1111名参与者 (25-83岁).
- 从2006年到2018年,每两年测量一次SUA度.
- 通过通用线性模型和调解分析,分析了SUA的变性 (斜率值) 和它与大脑结构,微观结构完整性,白质超强度,大脑小血管疾病和认知功能的关联.
主要成果:
- 增加或减少的SUA水平与较小的大脑白质体积相关.
- 逐渐增加的SUA水平与受损的微观结构完整性有关 (较低的分数异构性,更高的平均值和辐射扩散性).
- 升高的SUA水平与认知能力下降有关,白质缩和微观结构完整性受损调解了这种效应.
结论:
- SUA变化的程度,而不是它的方向,显著影响大脑健康,特别是在患有高尿血症的人群中.
- 大脑白质体积的减少和微观结构完整性的损害介导了SUA升高和认知衰退之间的联系.
- 建议长期保持SUA水平的稳定性,以保持大脑健康并防止认知能力下降.
相关概念视频
01:26Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
01:29Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
01:23Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...