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在患有重度抑郁症的患者中,rTMS与tDCS结合的认知增强作用:一项双盲,随机,假控制的双盲研究

Xingxing Li^1,2,3, Junyao Liu^2,3, Shuochi Wei¹

¹Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, China.

|June 20, 2024

概括

将重复性跨磁刺激 (rTMS) 与跨直流刺激 (tDCS) 结合起来,可显著改善主要抑郁症 (MDD) 患者的认知功能障碍和抑郁症状. 这种新疗法比单独治疗的任何一种疗法都提供了更大的好处.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
临床试验临床试验

背景情况:

认知功能障碍是患有严重抑郁症 (MDD) 患者的常见症状.
重复性跨磁刺激 (rTMS) 和跨直流刺激 (tDCS) 已显示出在治疗MDD认知障碍方面的潜力.
研究rTMS和tDCS的联合疗效对于新的治疗方法至关重要.

研究的目的:

评估将rTMS与tDCS结合用于改善MDD患者神经认知障碍的有效性和安全性.
为了比较结合rTMS和tDCS与单疗法和假药治疗的疗效.

主要方法:

这是一项为期2周的双盲,随机化,假控制试验,涉及203名MDD住院患者.
参与者接受了10次活跃或假的rTMS与活跃或假的tDCS相结合.
认知功能使用可重复电池评估神经心理状态 (RBANS) 进行评估,抑郁症状使用24项汉密尔顿抑郁评分表 (HDRS-24).

主要成果:

与假装治疗相比,联合rTMS和tDCS组在RBANS总得分,即时记忆和视觉空间/结构指数中显著改善 (p <0.05).
结合疗法导致HDRS-24得分的更大降低和更好的抑郁反应率,而不是单一干预.
虽然单独使用活性rTMS可以提高RBANS总得分,但对于其他认知领域,单一疗法都没有优势.

结论:

结合rTMS和tDCS是一种比单独治疗更有效的治疗MDD患者的认知功能障碍和抑郁症状.
这种组合疗法为管理MDD中神经认知缺陷提供了一个有希望的新策略.

关键词:

临床试验临床试验是指临床试验的临床试验.认知认知是一种认知.大型抑郁症主要是抑郁症.rTMSMS是因为 tDCSCS 是一个很好的方法.

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