系统性炎症是心脏代谢指数与死亡率之间缺失的联系吗? 来自一项基于人口的大规模研究的证据
Bin Xu1,2, Qian Wu3,4, Rui La5
1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
高心脏代谢指数 (CMI) 与老年人全因死亡率的增加有关. 这种关联部分是由炎症解释的,这表明CMI预测了这个人群的不良结果.
科学领域:
- 老年学是指老年学的学科.
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
背景情况:
- 心脏代谢指数 (CMI) 是一种与代谢相关的指数.
- 了解CMI对老年人死亡率的影响至关重要.
- 炎症在CMI相关死亡率中的作用需要进一步研究.
研究的目的:
- 检查CMI与老年人所有原因和心血管死亡率之间的关联.
- 探索炎症在这些关联中的潜在调解作用.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) (2005-2016) 65岁以上的3029名参与者的数据.
- 采用考克斯回归和子组分析来评估CMI与死亡率的关联.
- 通过调解分析,通过白细胞,中性粒细胞和SII指标研究炎症的调解效应.
主要成果:
- 在平均年龄为73.28±5.50岁的参与者中观察到0.74±0.66的平均CMI.
- 在经过89.20个月的随访后,发生了1015起全因死亡和348起心血管死亡.
- 升高的CMI与全因死亡率 (HR=1.11,95%CI=1.01-1.21) 有积极关联,其中白细胞和中性粒细胞的部分介导.
结论:
- 较高的CMI与老年人全因死亡率有关.
- 炎症途径部分调解了CMI和死亡率之间的关系.
- CMI可以作为老年人不良结果的有价值的预后指标.
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