基于工业级可扩展载体材料的双重装载纳米农药系统,具有组合效率和改进的安全性
Ningjun Li1, Jianxia Cui1, Jianjiang Zhao2
1Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Journal of nanobiotechnology
|June 20, 2024
概括
一种新型纳米农药输送系统 (BPDN) 含有博斯卡利德和皮拉克洛斯特罗宾,可提供延长,稳定的释放,提高可持续农业的有效性和安全性. 这种可扩展的技术减少了应用频率和劳动力成本.
科学领域:
- 农业化学 农业化学
- 纳米技术纳米技术
- 可持续农业 可持续农业
背景情况:
- 单一化学农药的广泛使用引发了安全性和效率方面的担忧.
- 商业农药配方通常具有不可调节的释放率,需要频繁的应用.
- 为实地应用扩大纳米农药输送系统的规模对于实际使用至关重要.
研究的目的:
- 开发一个可扩展的,双重加载的纳米农药系统 (BPDN) 使用博斯卡利德和皮拉克洛斯特罗宾.
- 使用表面活性剂优化BPDN的工业规模制备.
- 评估BPDN系统的性能,稳定性和安全性.
主要方法:
- 使用工业级载体构建波斯卡利德和皮拉克洛斯特罗宾双载纳米农药系统 (BPDN).
- 优化BPDN制剂通过研究表面活性剂,特别是农业乳化剂No.600和聚碳酸盐在1:2的比例.
- 与商业配方相比,BPDN的物理稳定性,释放率,分散,扩散,沉积和损失的评估.
- 在HepG2细胞和虫上进行毒理学试验.
主要成果:
- 最佳的BPDN配方呈现出具有卓越物理稳定的球形结构 (平均尺寸为270nm).
- 据证明,BPDN的速度稳定释放时间比商业配方长5倍.
- BPDN显示了叶片分散,扩散和沉积的增强 (增加了20%以上),损失减少.
- 一次BPDN应用有效控制了番茄灰,减少了应用时间和成本.
- 毒理学研究表明,对HepG2细胞和虫的安全性有所改善.
结论:
- 开发的BPDN系统提供了安全,高效和可扩展的农药配送解决方案.
- 由于BPDN的长期和受控释放特性,提高了疗效,减少了对环境的影响.
- 这项研究通过减少劳动力,成本和提高农药安全性来支持可持续农业.
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