改变第三个95的计数方式:适合测量U=U的指标与台湾的发现
Hsun-Yin Huang1, Yu-Ching Huang2, Hsiu-Yun Lo3
1Division of Chronic Infectious Diseases, Centers for Diseases Control, No. 6 Linsen South Road, Taipei, 100, Taiwan.
AIDS research and therapy
|June 20, 2024
概括
这项研究发现,虽然大多数艾滋病毒患者实现了病毒抑制,但9.3%的患者缺乏持续的长期控制. 年龄较小和教育程度较低等因素会影响持续的病毒载量抑制.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 病毒学 病毒学
背景情况:
- 世界卫生组织 (WHO) 目标是到2030年实现95-95-95的艾滋病毒治疗目标.
- 精确测量病毒抑制质量对于有效的艾滋病毒治疗至关重要.
- 目前用于病毒抑制的指标有所不同,使质量评估复杂化.
研究的目的:
- 为了检查艾滋病毒患者的长期病毒负载抑制.
- 确定影响持续病毒载荷控制的因素.
- 为了评估不同的病毒载量抑制指标.
主要方法:
- 对2019-2020年活着的艾滋病毒患者的病毒载荷测试数据的分析.
- 计算持久性病毒抑制,病毒病复制年和病毒载量> 1,500 个副本/毫升.
- 评估与非持久性病毒载荷抑制相关的因素.
主要成果:
- 在27,706名患者中,87%的患者实现了持续的病毒载量抑制.
- 96%的病毒载量在最后一次测量时无法检测,但9.3%缺乏持续的长期抑制.
- 不持久的抑制与年龄较小,教育程度较低,注射药物使用和医疗保健连续性较低有关.
结论:
- 持续的病毒载量抑制是评估艾滋病毒传播风险的关键指标.
- 将持续病毒载量抑制与其他指标相结合,可提供更准确的风险评估.
- 识别风险人群是改善长期艾滋病毒管理的关键.
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