益生菌对患有自闭症谱系障碍的儿童的影响:元分析
Ping Zeng1,2,3, Cheng-Zhi Zhang1,2,3, Zhi-Xing Fan1,2,3
1Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, 443003, China.
Italian journal of pediatrics
|June 20, 2024
概括
益生菌可以改善患有自闭症谱系障碍 (ASD) 的儿童的肠道健康,但这次元分析没有发现ASD核心症状或行为有显著改善. 需要进一步的研究来证实这些发现.
科学领域:
- 胃肠病学 胃肠病学
- 神经发育障碍 神经发育障碍
- 微生物组研究 微生物组研究
背景情况:
- 肠道微生物群的变化越来越多地与自闭症谱系障碍 (ASD) 的发展有关.
- 益生菌补充剂对ASD的有效性仍然是正在进行的辩论和研究的主题.
- 这一元分析调查了益生菌对自闭症儿童的影响.
研究的目的:
- 系统地评估在被诊断为自闭症谱系障碍 (ASD) 的儿童中补充益生菌的结果.
- 为了确定益生菌是否对ASD症状和相关行为产生有益影响.
主要方法:
- 在主要数据库 (PubMed,Cochrane Library,Web of Science,Embase) 进行了全面的文献搜索,截至2022年9月.
- 包括随机对照试验 (RCT),比较ASD儿童的益生菌与安慰剂.
- 评估结果包括行为尺度 (ABC,CBCL),社会反应能力 (SRS),发育系数 (DQ),整体改善 (CGI-I) 和胃肠道严重程度 (6-GSI).
主要成果:
- 分析了涉及302名儿童的6项RCT.
- 益生菌的使用导致6项胃肠道严重性指数 (6-GSI) 的统计学显著下降.
- 在益生菌和安慰剂组之间的行为指标 (ABC,CBCL),社会反应能力 (SRS),发育系数 (DQ) 或整体临床改善 (CGI-I) 中没有发现显著差异.
结论:
- 益生菌补充剂显示出减轻ASD儿童胃肠道症状的潜力.
- 目前的证据不支持使用益生菌对核心自闭症谱系障碍症状或行为显著改善.
- 需要进一步的研究,以充分理解益生菌在治疗ASD中的作用.
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