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晚期生物中的性二态性帕拉马克罗比亚托斯 (Paramacrobiotus metropolitanus) 转录组

Kenta Sugiura¹, Yuki Yoshida², Kohei Hayashi¹

¹Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa, 223-8522, Japan.

Zoological letters

|June 20, 2024

概括

研究人员探索了晚级生物的性二态性,识别了男性偏向的双性-Mab-3相关转录因子 (DMRT) 基因. 这项研究揭示了晚级动物性决定的遗传基础及其应激耐受机制.

科学领域:

动物学和遗传学动物学和遗传学
进行比较基因组学.
进化生物学进化生物学

背景情况:

性二态性是常见的,在gonokoristic动物,由性别确定途径驱动.
双性-Mab-3相关的转录因子 (DMRT) 是跨种群性差异化的保守调节者.
晚级动物表现出显著的性二态,但遗传基础仍然在很大程度上未被探索.

研究的目的:

为了研究性二重形的分子基础,在迟缓的物种Paramacrobiotus metropolitanus.
为了确定雄性和雌性尾动物之间的特定性别的基因组和转录组差异.

主要方法:

在性别识别样本上进行了包括转录组测序在内的Omics分析.
遗传学分析被用来追踪关键的性别决定基因的进化历史.
差异基因表达分析确定了男性偏见的基因和基因组位置.

主要成果:

大约有2000个男性偏差基因被确定,来自29个非性别特异性基因组位点.
在男性中,两种特定于Macrobiotidae家族的DMRT对应物被显著上调.
两性之间没有发现基因组差异,双性基因对象在形动物中不存在,这表明其在形动物后的分歧.

结论:

这项研究提供了一个基本的理解遗传差异和性决定级联在迟行者.
鉴定男性偏向的DMRT亚家族和男性偏向的基因组位点,为晚期性别确定提供了洞察力.
无水生菌病基因的性别偏差表达表明,在极端压力期间,它们在保护特定性别的组织和性质细胞中发挥着作用.

关键词:

在DMRT基因家族中,帕拉马克罗比乌托斯 (Paramacrobiotus metropolitanus) 是一个大都市的动物.基因组基因组基因组基因组基因组两性二形态主义是一种性别二形态主义.迟滞等级的迟滞等级的转录组转录组就是一个转录组.

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