结肠癌手术后的肠功能障碍:一个前性,纵向性,多中心研究
Sofia J Sandberg1,2, Jennifer M Park1,2, Viktor A Tasselius1,3
1Department of Surgery, Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Diseases of the colon and rectum
|June 20, 2024
概括
大多数患者在结肠切除后保持良好的肠功能,只有少数患者经历了显著的痛苦. 妇女报告了更多的症状,右侧切除后松散的便是常见的,突出了全面的术后评估的需要.
科学领域:
- 结肠直肠手术的结果
- 胃肠道功能恢复的恢复
- 患者报告的结果衡量患者报告的结果.
背景情况:
- 有限的纵向数据存在于结肠切除后的功能结果.
- 了解长期肠道功能障碍对于结直肠癌手术后患者的生活质量至关重要.
研究的目的:
- 为了评估肠道功能障碍和相关的痛苦,大肠切除后的一年和三年.
- 通过低前切除综合征 (LARS) 评分和特定的验证项目来评估功能结果.
主要方法:
- 展望性,观察性,多中心研究 (结肠癌患者的生活质量 - QoLiCOL) 涉及1221名患者.
- 患者在诊断时,手术后1年和3年填写了问卷.
- 评估的低前切除综合征 (LARS) 评分,特定的肠道症状,以及患者报告的痛苦.
主要成果:
- 17%的患者在切割后一年报告了LARS,在三年内一致 (17%右,16%左).
- 在右侧切除后,松散的便更频繁;失禁和松散的便与痛苦有很强的相关性.
- 不到五分之一的患者经历了痛苦,女性报告了更频繁的症状和更大的痛苦.
结论:
- 结肠切除后,肠道功能在很大程度上保持完整,大多数患者报告的严重痛苦最小.
- 不良结果,特别是症状和痛苦的增加,在女性中更为普遍.
- 该研究强调,需要进行超越LARS得分的综合性术后评估,特别是对于松的便和失禁.
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