重复的COVID-19疫苗接种驱动了移植患者的记忆T细胞和B细胞反应:多中心随机对照试验的结果
S Reshwan K Malahe1, Yvette den Hartog1, Wim J R Rietdijk2
1Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Transplantation
|June 21, 2024
概括
提升COVID-19疫苗接种显著改善了移植接受者 (KTRs) 的免疫反应,增加了血清转化率. 病毒特异性记忆T细胞和B细胞反应是了解KTRs疫苗疗效的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 移植 移植 移植 移植
背景情况:
- 为移植接受者 (KTRs) 优化COVID-19助推计划,需要了解细胞免疫反应.
- KTRs通常对初始的mRNACOVID-19疫苗接种表现出低于最佳的血清反应.
研究的目的:
- 为了比较KTRs中不同COVID-19疫苗接种策略后的SARS-CoV-2特异性T细胞和B细胞反应.
- 评估不同疫苗接种方案和免疫抑制策略对KTRs免疫记忆的影响.
主要方法:
- 一个随机对照试验的免疫学副研究,涉及KTRs与先前的疫苗反应不佳.
- 通过ELISpot测定和血清IgG抗体水平,评估了SARS-CoV-2特异性介素-21记忆T细胞和B细胞反应.
- 对不同mRNA和腺病毒载体疫苗策略的反应进行了比较,并评估了停止使用mycophenolate mofetil的效果.
主要成果:
- 重复接种疫苗使KTRs的整体血清转化率从21%增加到66%.
- 增强SARS-CoV-2特异性记忆T细胞和B细胞水平与血清转化有很强的相关性.
- 抗原特异性记忆B细胞显示出在重复接种疫苗后分类血清转换的潜力.
结论:
- 病毒特异性记忆T细胞和B细胞反应对于全面了解KTRs中COVID-19疫苗疗效至关重要.
- 这些发现凸显了细胞免疫评估在评估免疫受损人群中疫苗有效性的重要性.
相关概念视频
Cell-mediated Immune Responses
68.1K
Overview
68.1K
Immunological Memory
590
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
590
Vaccinations
44.4K
Overview
44.4K
Cells of the Adaptive Immune Response
979
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
979
Immune Response Against Viral Pathogens
775
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
775
Cytotoxic T Cells-mediated Immune Response
889
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
889


