通过整合远程医疗和分散治疗来促进临床试验公平
Eleanor Brown1, George Albert Fisher2, Andrew Shelton3
1Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, CA, USA.
JNCI cancer spectrum
|June 21, 2024
概括
分权化临床试验治疗可以改善代表性不足的群体的可访问性. 在第二阶段试验中,局部化疗管理减少了参与者的旅行负担,提高了临床研究公平性.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 健康 公平 卫生 公平
背景情况:
- 创新策略对于提高临床试验可访问性和公平性至关重要.
- 分散的临床试验设计可以改善不同患者群体的获取.
研究的目的:
- 评估在II期试验中分散研究治疗是否能改善代表性不足的群体的可访问性.
- 评估局部化疗给药对参与者的旅行负担的影响.
主要方法:
- 一个由研究人员发起的II期试验的回顾性审查.
- 在接受本地化疗的参与者与没有接受当地化疗的参与者之间,对社会人口统计学特征,地区贫困指数和旅行负担 (距离,时间,成本) 的比较.
主要成果:
- 接受局部化疗的参与者旅行的距离明显更远 (中位数为95.90与25.20英里,P=.004).
- 当地化疗给药导致更大的时间负担 (中位数为115.00分 vs 34.00分钟,P=.002) 和更高的旅行费用 (中位数为62.81美元 vs 16.51美元,P=.004).
结论:
- 分散临床试验治疗可以减轻参与者的财务和时间负担.
- 修改临床试验设计以包括局部治疗管理,促进了临床研究中的更大公平性.
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