菌 Pseudopneumoniae 和 Streptococcus salivarius 对声粘膜完整性和功能的贡献
Vlasta Lungova1, Madhu Gowda1, Jessica M Fernandez1
1Department of Surgery, Division of Otolaryngology, University of Wisconsin-Madison, Madison, WI 53792, USA.
Disease models & mechanisms
|June 21, 2024
概括
这项研究揭示了Streptococcus pseudopneumoniae如何破坏声 (VF) 表皮完整性,导致炎症. 相反,开始性Streptococcus salivarius通过减少炎症和促进细胞脱落来保护VF粘膜.
科学领域:
- 微生物学 微生物学
- 细胞生物学 细胞生物学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 声 (VF) 良性病变与结构性变化有关,例如放松的细胞间结.
- 寄居微生物群落在VF上皮干扰中的作用尚不清楚.
研究的目的:
- 为了研究Streptococcus pseudopneumoniae (SP) 和Streptococcus salivarius (SS) 与人类VF上皮细胞之间的相互作用.
- 阐明这些细菌影响VF粘膜完整性和炎症的机制.
主要方法:
- 利用人类VF粘膜的三维模型直接暴露于细菌.
- 在细胞,分子和超结构层面评估了细菌与宿主之间的相互作用.
- 分析了SP和SS对VF上皮质完整性和炎症反应的影响.
主要成果:
- Streptococcus pseudopneumoniae (SP) 破坏了VF的上皮完整性,并通过出口产品 (HtrA1,pneumolysin) 引发炎症.
- 杆菌 (Streptococcus salivarius,SS) 附着在VF表皮上,减少炎症,并诱导Mmp2-介导的顶部脱皮.
- SS减轻了致病细菌对VF上皮细胞的影响.
结论:
- 微生物群落在VF病理学中起着复杂的作用.
- 像SS这样的喉开始者可能有助于VF粘膜的恢复和对病原体的保护.
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