在非中风的成年人中,动脉内膜介质厚度和白质过强度之间的关系:系统性审查
Syeda Humayra1, Noorazrul Yahya2, Chai Jia Ning1,3
1Makmal Pemprosesan Imej Kefungsian (Functional Image Processing Laboratory), Department of Radiology, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Frontiers in neuroanatomy
|June 21, 2024
概括
这次审查发现,在没有中风的成年人中,较厚的动脉壁和大脑中更多的白质损伤之间存在联系. 动脉样硬化可能导致大脑白质变化.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 放射学 放射学是一门学科.
背景情况:
- Carotid 动脉样硬化 (CAS) 和大脑中的白质变化共享潜在的病理生理联系.
- 喉内膜厚度 (CIMT) 与白质强度 (WMH) 之间的关联需要进一步澄清.
研究的目的:
- 系统地审查和报告在无症状或非中风的成年人中CIMT和WMH之间的关系.
主要方法:
- 使用PubMed,SCOPUS和Web of Science数据库进行了系统的文献搜索,并遵循PRISMA协议.
- 包括符合PICOS标准的观察性研究,研究使用MRI和带超声波在非中风成年人中CIMT-WMH相关性.
主要成果:
- 分析了10项高质量的研究,涉及5116名参与者 (36-71岁).
- 在50%的研究中观察到增加CIMT和增加WMH负担之间的并行关系.
- 风险因素包括年龄较大,高血压,抑郁症,偏头痛,西班牙裔族裔和绝经后妇女的APOE ɛ4.
结论:
- 一致的证据支持在无症状的中年和老年人中CIMT-WMH关联.
- 动脉样硬化可能在白质强度过高的进展中起作用.
- 需要进一步的研究,以充分阐明CIMT-WMH的关系在没有中风的情况下.
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