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扫描器内思想塑造休息状态的功能连接:参与者如何"休息"是很重要的

J Gonzalez-Castillo¹, M A Spurney¹, K C Lam²

¹Section on Functional Imaging Methods, NIMH, NIH, Bethesda, Maryland, USA.

bioRxiv : the preprint server for biology

|June 21, 2024

概括

静止状态功能连接 (rs-FC) 受参与者在扫描器中的体验的影响. 心灵游荡和其他主观状态显著改变了rs-FC模式,影响了临床研究结果.

科学领域:

神经成像是一种神经成像.
认知神经科学认知神经科学
精神病学是一个精神病学.

背景情况:

休息状态功能连接 (rs-FC) 分析对于识别临床人群中的大脑变化至关重要.
对于运动和人口统计等混的标准预处理控制,但不是主观的经验.

研究的目的:

调查扫描器内主观体验对rs-FC测量的影响.
确定rs-FC是否可以预测扫描器内体验的特定方面.

主要方法:

分析了471个休息状态fMRI (rs-fMRI) 扫描与相关的经验数据.
基于报道的扫描器内体验的FC模式的统计比较.
机器学习模型用于从FC数据中预测体验方面.

主要成果:

在不同扫描器体验的扫描之间观察到rs-FC的显著广泛差异.
rs-FC成功地预测了人口,认知和临床变量,类似于它对主观经验的预测能力.

结论:

在扫描仪中的经验是影响rs-fMRI衍生FC的关键因素.
未来的rs-fMRI研究必须考虑主观状态,以提高可解释性和减少混.

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