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创伤性脑损伤后风险:全国性的挪威匹配队列研究

Hild Flatmark Sødal^1,2, Trond Nordseth^3,4, Anders Johan Orland Rasmussen^1,5

¹Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Frontiers in neurology

|June 21, 2024

概括

在创伤性脑损伤 (TBI) 后,创伤后 (PTE) 的风险更高. 这项研究发现PTE发病率低于以前报告的,特别是在中度至重度TBI后.

科学领域:

神经学神经学
流行病学流行病学
创伤研究创伤研究

背景情况:

创伤后 (PTE) 是创伤性脑损伤 (TBI) 的已知并发症.
预测PTE仍然具有挑战性,因为不断变化的TBI治疗和人口统计数据可能会影响风险.
这项研究旨在利用全国性登记册更新PTE发病率估计.

研究的目的:

为提供创伤后 (PTE) 发病率的最新估计.
分析PTE风险与创伤性脑损伤 (TBI) 严重程度和患者人口统计学相关.
将TBI患者的PTE发病率与一般人群进行比较.

主要方法:

使用了一种匹配的队列研究设计,将挪威创伤登记处与全国登记处联系起来.
患有TBI (2015-2018) 的患者与无创伤的对照人进行了匹配,并对发病诊断进行了跟踪 (2015-2020).
计算了累积发病率,根据受伤严重程度 (AIS,GCS) 和年龄分层分析.

主要成果:

该研究包括8,660名TBI患者和84,024名对照.
在TBI患者中,累计PTE发病率在2年后为3.1%,在5年后为4.0%,而对照组中为0.2%和0.5%.
严重的TBI (AIS) 和40岁以上的年龄与最高的PTE发病率有关.

结论:

与对照组相比,患有TBI的患者面临患的风险显著增加.
观察到的PTE发病率,特别是中度至重度的TBI,低于之前记录的.
这些更新的数据提供了关键的见解,对目前的PTE风险TBI后.

关键词:

简称的伤害量表.流行病学流行病学发生率的发生率.后创伤性 - - 后创伤性创伤性脑损伤是一种创伤性脑损伤

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