德克斯梅德托米丁用于降低在接受电治疗的患者中因顺胆引起的肌痛:一项随机对照试验
Bhavna Sriramka1, Sasmita Panigrahy1, Mathan Kumar Ramasubbu2
1Department of Anesthesia, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
Indian journal of anaesthesia
|June 21, 2024
概括
低剂量德克斯梅德托米丁在接受电疗法 (ECT) 的患者中有效降低了肌肉疼痛和筋. 这种干预提供了一种有希望的方法来缓解在ECT中使用的顺胆的常见副作用.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
背景情况:
- 电疗法 (ECT) 是对精神疾病的重要治疗方法.
- 苏奇尼尔胆经常用于ECT期间的肌肉松.
- 苏奇尼尔胆可以引起显著的副作用,如肌痛和结.
研究的目的:
- 为了评估低剂量德克斯梅德托米丁在缓解顺胆诱导肌痛方面的疗效.
- 评估德克斯梅德托米丁对基尼尔胆诱导的结的影响.
- 为了比较在ECT期间接受德克斯梅托米丁与安慰剂的患者的血液动力学变化.
主要方法:
- 一项随机对照试验,涉及100名接受ECT的患者.
- 患者接受了静脉注射的德克斯梅德托米丁 (0.25微克/千克) 或正常盐水.
- 肌痛,筋,心率和血压都被监测.
主要成果:
- 在德克斯梅托米丁组 (P < 0.001) 观察到明显较低的肌痛和结得分.
- 两组之间没有注意到心率或平均血压变化的显著差异 (P > 0.05).
- 治疗组和对照组的人口统计数据相似.
结论:
- 低剂量的德克斯梅德托米丁 (0.25微克/千克) 有效地减少因顺胆引起的肌痛和结.
- 德克斯梅德托米丁 (Dexmedetomidine) 是一种安全有效的补充剂,用于管理与ECT相关的副作用.
- 这一发现支持使用德克斯梅德托米丁来改善ECT期间患者的舒适度.
相关概念视频
Skeletal Muscle Relaxants: Adverse Effects
354
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
354
Depolarizing Blockers: Pharmocokinetics
318
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
318
Skeletal Muscle Relaxants: Therapeutic Uses
480
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
480
Depolarizing Blockers: Mechanism of Action
1.5K
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
1.5K
Electroconvulsive Therapy
31
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
31
Sedatives and Hypnotics Drugs: Miscellaneous Agents
168
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
168


