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对免疫检查点抑制剂的抵抗机制的进一步知识和发展
Léa Berland1,2, Zeina Gabr2,3, Michelle Chang2
1Inserm U1081 Institute for Research on Cancer and Aging, Nice (IRCAN) Team 4, Université Côte d'Azur, Institut Hospitalo Universitaire (IHU) RespirERA, Federation Hospitalo Universitaire (FHU) OncoAge, Nice, France.
Frontiers in immunology
|June 21, 2024
概括
癌症治疗方法正在发展,但许多患者对免疫检查点抑制剂 (ICI) 等免疫疗法没有反应. 了解瘤抵抗机制是改善癌症护理和克服治疗失败的关键.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 癌症治疗已经从化疗转向向疗法和免疫疗法,包括免疫检查点抑制剂 (ICI).
- ICI利用宿主免疫系统对抗癌症,在以前无法治愈的癌症如转移性黑色素瘤,细胞癌 (RCC) 和非小细胞肺癌 (NSCLC) 中实现持久缓解.
- 仍然是一个重大挑战,因为大约80%的患者对当前的免疫疗法没有反应.
研究的目的:
- 审查最近在瘤免疫学过程中的发现.
- 探索这些过程如何影响瘤微环境.
- 了解对PD-1/PD-L1检查点阻塞疗法的耐药性机制.
主要方法:
- 关于最近科学发现的文献评论.
- 对瘤免疫学过程的分析.
- 研究影响治疗反应的瘤微环境因素.
主要成果:
- 确定了瘤微环境中的关键瘤免疫机制.
- 突出了导致ICI原发性和获得性耐药性的因素.
- 详细介绍了癌细胞如何适应克服PD-1/PD-L1阻塞.
结论:
- 了解瘤抵抗机制对于提高癌症治疗疗效至关重要.
- 绕过ICI的耐药性可以改善患者的治疗结果.
- 需要对瘤微环境进行进一步的研究,以克服免疫疗法失败.
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