血清水平与严重急性骨髓炎患者的预后之间的相关性
Yunlong Liu1, Yan Zheng2, Sheng Ding1
1Department of Pediatric Surgery, Women and Children's Hospital Affiliated to Ningbo University, Ningbo, Zhejiang, China.
Frontiers in immunology
|June 21, 2024
概括
低血清水平是严重急性骨髓炎患者死亡率的重要预测因素. 这一发现强调了的含量.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 临床生物化学 临床生物化学
背景情况:
- 严重的急性骨髓炎对患者的生存构成重大威胁.
- 严重急性骨髓炎的预后标志物对于及时干预至关重要.
- 血清水平在骨髓炎预后中的作用仍未得到充分研究.
研究的目的:
- 调查血清水平与严重急性骨髓炎的预后之间的关联.
- 评估血清在预测这些患者的结果中的有用性.
主要方法:
- 从MIMIC-IV.进行的1133例严重急性骨髓炎病例的回顾性分析.
- COX回归分析以确定预后指标.
- 开发和验证使用ROC和校准曲线进行生存预测的诺米克图.
主要成果:
- 较低的血清 (Ca2+) 水平与死亡率的增加显著相关.
- 多变量分析确定了年龄,高血压,败血症,血红蛋白,白蛋白,肌素和Ca2+作为显著的预后因素.
- 开发的名图表显示出强大的预测准确性,AUC为0.841.
结论:
- 血清水平降低是严重急性骨髓炎死亡率的独立预测因素.
- 血清水平可以有效地用于ICU重症急性骨髓炎患者的预后评估.
相关概念视频
01:21Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K
01:25Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:31Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K