英国心力衰竭风险的区域差异部分归因于生物衰老
Jason Y Y Wong1, Batel Blechter2, Erik J Rodriquez1
1Epidemiology and Community Health Branch, National Heart Lung and Blood Institute, Bethesda, MD, United States.
Frontiers in public health
|June 21, 2024
概括
心力衰竭 (HF) 的风险在农村地区更高,即使有全民医疗保健. 受到生活方式因素影响的生物衰老部分解释了这种风险增加,这表明了新的干预目标.
科学领域:
- 心血管流行病学心血管流行病学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 心力衰竭 (HF) 的风险在美国农村地区比城市地区更高,这归因于医疗保健获取差异.
- 目前尚不清楚这种差异是否存在于普遍医疗保健和涉及的生物机制的国家.
- 这项研究调查了城市和农村的高频风险差异以及英国生物库中生物衰老的作用.
研究的目的:
- 检查英国心力衰竭 (HF) 风险的城乡差异.
- 调查生物衰老在调解HF风险中的机制性作用.
- 探索精确公共卫生干预的潜在目标.
主要方法:
- 使用英国生物库 (417.441名参与者) 的前性队列研究.
- 多变量考克斯回归用于评估与城乡地区相关的高频风险和生物健康评分 (BHS).
- 分析城市和农村对HF影响的比例,由BHS.中介.
主要成果:
- 与苏格兰相比,在英格兰/威尔士观察到HF风险增加,在较小的城市,郊区和非常农村地区风险更高.
- 在增加的生物衰老和HF风险之间发现了剂量反应关系 (HR每1 SD增加=1.14).
- 生物衰老占城乡地区对HF风险总影响的6.6%.
结论:
- 在英国,尽管有普遍的医疗保健,但高频风险存在区域差异.
- 导致生物衰老的环境,社会和饮食因素可能解释了这些差异.
- 这些发现支持精确的公共卫生方法,通过确定生物衰老作为潜在的干预目标.
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