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单次和混合暴露于多环芳和生物衰老之间的关联

Zuqiang Fu¹, Xianli Zhang², Chunyu Zhong²

¹School of Public Health, Southeast University, Nanjing, Jiangsu, China.

Frontiers in public health

|June 21, 2024

概括

多环芳 (PAHs) 暴露与加速衰老有关,特别是PhenOAge加速. 鉴定出2-纳夫托是这种衰老效应的重要贡献者,突出了特定的PAH成分作为衰老风险因素.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
老年学是指老年学的学科.

背景情况:

衰老是一个关键的公共卫生问题.
以前关于衰老因素的研究忽略了多环芳 (PAHs).
氧化和生物衰老之间的关联需要进一步研究.

研究的目的:

研究多环芳 (PAH) 与生物衰老之间的关系.
确定有助于加速衰老的特定PAH成分.
探索混合PAH暴露对衰老的综合影响.

主要方法:

利用了来自8,100名参与者的国家健康和营养检查调查 (NHANES) 数据 (2003-2010年).
使用Klemera-Doubal方法 (KDM) 和Mahalanobis距离来预测生物年龄.
评估单个和混合PAH对KDM-BA和PhenoAge加速的影响,使用回归和加权量子积 (WQS) 模型.

主要成果:

对PAH的暴露与PhenoAge加速有显著的相关性.
增加的1-纳夫托尔,2-纳夫托尔和2-的水平与更高的PhenoAge加速相关.
混合PAH暴露与KDM-BA和PhenoAge加速有关,在WQS分析中,2-naphthol显示出最大的影响.

结论:

混合多环芳 (PAH) 暴露与增加的生物衰老有关.
特定的PAH化合物,特别是2-纳,是PAH诱导衰老的关键因素.
确定PAH成分作为加速衰老的重要风险因素.

关键词:

尼汉斯 (NHANES) 是一个名人.这些PAH是PAH.老化的老化衰老的老化协会研究协会研究混合暴露的混合暴露.

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