血清25-基维生素D水平与COPD患者全因死亡率之间的非线性相关性和中介效应
Qi Jiang1, Yuewen Jiang2, Zheru Ma3
1Department of Respiratory and Critical Care Medicine, First Hospital of Jilin University, Changchun, China.
Frontiers in nutrition
|June 21, 2024
概括
较高的维生素D水平 (25-氧维生素D) 与慢性阻塞性肺病 (COPD) 患者的死亡率降低有关. 维持足够的维生素D可能对改善COPD患者的生存率至关重要.
科学领域:
- 肺部医学 肺部医学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 低维生素D水平与炎症性疾病的风险增加和进展有关.
- 维生素D对慢性阻塞性肺病 (COPD) 患者死亡率的影响尚不清楚.
研究的目的:
- 研究血清25-氧维生素D[25(OH) D]水平与美国成年人被诊断患有慢性肺炎的全因死亡风险之间的关联.
主要方法:
- 来自国家健康和营养检查调查 (2005-2018) 的1876名COPD患者的分析,使用来自国家死亡指数的死亡率数据.
- 将参与者分为维生素D缺乏,不足和充足的组,根据25...OH) D水平进行分类.
- 使用了权重考克斯回归,卡普兰-梅尔生存分析,子组/敏感性分析,受限立方线和中介分析.
主要成果:
- 总共有395人死亡,死亡率为21.06%.
- 较高的25~OH) D水平与COPD患者全因死亡风险较低显著相关 (HR=0.52).
- 观察到非线性L形关系,低于63.4nmol/L的水平独立增加死亡风险.
结论:
- 血清25-基维生素D独立降低了COPD患者的全因死亡风险.
- 维生素D水平与死亡率之间的关系是非线性的 (L形).
- 维生素D调解了饮食炎症指数对死亡率的影响的22%,这表明了治疗潜力.
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