薄膜细胞淋巴瘤的特点是整个消化道沿着众多的扩散型多性病变:一个病例报告
Siqi Cheng1, Li Yang1, Xiangyang Wang1
1Department of Gastroenterology, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, Hunan 410000, P.R. China.
Oncology letters
|June 21, 2024
概括
本报告详细介绍了一种罕见的上衣细胞淋巴瘤 (MCL),影响整个胃肠道,呈现为扩散多性病变. 尽管预后不好,但有效的治疗导致了完全的反应.
科学领域:
- 胃肠道瘤学 胃肠道瘤学
- 血液学恶性瘤是什么
- 临床病例报告 临床病例报告
背景情况:
- 初级上衣细胞淋巴瘤 (MCL) 在胃肠道并不常见,占GI非霍奇金淋巴瘤的4-9%.
- 广泛的胃肠道参与MCL是非常罕见的.
- 这种病例突显出一种独特的MCL呈现,在整个消化系统中具有扩散的多重型病变.
研究的目的:
- 描述一种罕见的上衣细胞淋巴瘤 (MCL) 病例,严重影响了胃肠道.
- 为了说明与这种罕见的MCL呈现相关的内镜检测结果.
- 讨论广泛的胃肠道MCL的治疗策略和结果.
主要方法:
- 一个患有胃肠道扩散多型病变的患者的详细病例报告.
- 内镜检查和活检用于地幔细胞淋巴瘤的组织病理学诊断.
- 审查患者的治疗方案,包括初始和修改的化疗和向治疗.
主要成果:
- 该患者在整个胃肠道中呈现出众多的扩散型多性病变.
- 最初的治疗包括Rituximab和CHOP化疗,随后是修改后的治疗方案,包括Rituximab,Etoposide,Oxaliplatin,Ifosfamide和Ibrutinib.
- 通过治疗方案,实现了完整的反应.
结论:
- 覆膜细胞淋巴瘤涉及整个胃肠道是一个罕见的实体,具有明显的内镜外观.
- 积极的治疗策略,包括组合化疗和向治疗,如易布鲁替尼,可以导致完全缓解.
- 这一案例强调了在差异诊断中考虑罕见的胃肠道淋巴瘤的重要性,以及成功治疗结果的可能性.
相关概念视频
01:15Secondary Lymphoid Organs
1.4K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.4K
01:30Inflammatory Bowel Disease II: Crohn's Disease
213
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
213
01:27Histology of the Small Intestine
689
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
689
01:17Chronic Bowel Disorders: Introduction
440
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
440
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
161
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
161
01:26Histology of the Large Intestine
680
The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
680