休息状态网络和阿尔茨海默氏病中的无意识症
Manuela Tondelli1,2,3, Daniela Ballotta1, Riccardo Maramotti1,4,5
1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Frontiers in aging neuroscience
|June 21, 2024
概括
阿尔茨海默病中的无意识与大脑网络连接的改变有关. 具体来说,降低默认模式网络 (DMN) 和前端对象网络 (FPN) 的连接性,以及增加突出网络 (SN) 的连接性,与对认知缺陷的不意识有关.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
- 神经成像是一种神经成像.
背景情况:
- 在阿尔茨海默氏症 (AD) 中,无意识或对认知障碍的不意识,可能源于大脑网络连接中断.
- 默认模式网络 (DMN) 中的连接性降低和前带皮层 (ACC) 功能的改变与AD anosognosia有关.
- 这项研究调查了在阿尔茨海默病中出现的无意识症与默认模式网络 (DMN),突出网络 (SN) 和前端对称网络 (FPN) 之间的不平衡相关的假设.
研究的目的:
- 检查在患有轻度认知障碍 (MCI) 和AD痴呆症的患者的大脑网络中的无意识和功能连接之间的关系.
- 为了确定特定的网络连接模式,与AD连续性的认知缺陷的不意识相关.
主要方法:
- 60名患有MCI和AD痴呆症的患者接受了休息状态功能磁共振成像 (fMRI) 和神经心理测试,包括Anosognosia问卷痴呆症 (AQ-D).
- 使用独立组件分析 (ICA) 来分析休息fMRI数据.
- 评估了AQ-D得分与DMN,SN和FPN内的功能连接之间的相关性,以及意识到和不意识到的患者组之间的比较.
主要成果:
- 无意识与DMN内的功能连接性较弱有关,特别是在后侧和中间带带皮层.
- 在无症状患者中观察到,SN内部,特别是ACC内以及SN与基底腺之间具有更强的功能连接.
- FPN显示异质的连接模式,与PCC的连接较弱,与ACC的连接较强.
结论:
- 阿尔茨海默病连续体中的无意识症的特点是DMN,SN和FPN的功能连接的失调.
- 这些发现凸显了大规模网络不平衡在阿尔茨海默病患者缺乏意识的表现中的作用.
- 针对这些网络调节障碍可能为改善阿兹海默症患者意识提供潜在的治疗途径.
关键词:
这就是阿尔茨海默病的原因.没有任何的异常.默认模式的默认模式痴呆症 痴呆症是一种痴呆症.轻度的认知障碍 轻度的认知障碍静止状态网络 静止状态网络突出 突出 突出 突出 突出没有意识,没有意识.更多相关视频
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