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综合单细胞和转录组测序分析确定了PREX1作为肝肝细胞癌的免疫相关预后生物标志物

Jing Yang¹, Lin-Yin Fan², Kai-Yuan Shi¹

¹Department of Diagnostic Ultrasound Imaging & Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310022, China.

International journal of medical sciences

|June 21, 2024

概括

肝癌中PtdIns (3,4,5) P3-依赖的Rac交换剂1 (PREX1) 表达的升高与预后不佳和免疫细胞透的改变有关. PREX1可以作为免疫治疗反应的生物标志物和肝肝细胞癌 (LIHC) 的治疗标.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

PtdIns (3,4,5) P3-依赖的Rac交换器1 (PREX1) 是一种Rac关氨酸核酸交换因子,涉及癌症途径.
PREX1在肝肝细胞癌 (LIHC) 病原和免疫调节中的特定作用尚不清楚.

研究的目的:

研究PREX1在LIHC中的表达,临床意义和免疫学作用.
评估PREX1作为潜在的预后和免疫治疗响应的生物标志物在LIHC.

主要方法:

使用TCGA,TNM绘图器和UALCAN数据库分析PREX1表达和临床相关性.
通过TISIDB,CIBERSORT和单细胞分析,研究PREX1与免疫细胞和免疫疗法反应的关系.
在LIHC细胞系中进行功能性测试,以评估PREX1耗尽的影响.

主要成果:

在LIHC组织中,PREX1的表达显著更高,与不良的临床特征和不良预后相关.
PREX1的表达与免疫相关的途径有关,并且与特定的免疫细胞,特别是巨细胞有很强的相关性.
高PREX1表达与免疫治疗的增强反应以及在耗尽后抑制LIHC细胞入侵和增殖有关.

结论:

在LIHC中PREX1表达升高是预后不佳的标志物,并影响免疫调节.
PREX1预测了对免疫抑制疗法的敏感性,表明其作为预后生物标志物的潜力.
在新型LIHC治疗策略中,PREX1是一个有前途的治疗标.

关键词:

免疫系统的透.肝脏肝细胞癌是肝脏肝细胞癌.在PREX1中使用PREX1 预测预测预测预测一个单细胞分析.

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