正常和受伤的人类嗅觉上皮质的结构和功能
Shu Kikuta1, Shin Nagayama2, Sanae Hasegawa-Ishii3
1Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Nihon University, Tokyo, Japan.
Frontiers in neural circuits
|June 21, 2024
概括
嗅觉功能障碍,通常是由慢性鼻炎和病毒感染引起的,可能导致不可逆转的嗅觉损失. 虽然嗅觉上皮 (OE) 通常会再生,但严重的损伤可能会损害长期的嗅觉功能.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 细胞生物学 细胞生物学
背景情况:
- 嗅觉上皮 (OE) 易受环境损伤的影响,导致嗅觉感官神经元 (OSN) 损伤.
- 嗅觉功能障碍源于各种原因,包括创伤,神经退行性疾病,衰老,慢性鼻炎 (CRS) 和病毒感染.
研究的目的:
- 审查人类OE的组织结构和分布.
- 阐明CRS和病毒感染中嗅觉功能障碍的病原性.
主要方法:
- 文献综述侧重于OE组织学,OSN再生和嗅觉功能障碍的机制.
- 分析与CRS和病毒感染相关的OE病理变化的分析.
主要成果:
- 成熟的OSNs受伤会通过基底细胞增殖和分化触发再生.
- 慢性呼吸系统和病毒感染通过炎症,空气流量减少和细胞因子释放引起嗅觉功能障碍.
- 持续的炎症或严重的伤害可能会导致由于OE的形态变化而导致嗅觉功能的不可逆转损失.
结论:
- 了解OE结构和再生对于解决嗅觉功能障碍至关重要.
- 在CRS和病毒感染中的炎症过程显著导致嗅觉障碍.
- 严重或长期的OE损伤可能导致永久的嗅觉缺陷,突出需要有效的干预措施.
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