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甲状腺功能低下症和胃癌风险之间的因果关系:通过多变量门德尔随机化和调解分析获得的见解
Tianyue Zhang1, Jie Qiao1, Yuanyou Wang1
1Department of Endocrinology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Frontiers in endocrinology
|June 21, 2024
概括
甲状腺功能低下症可能会防止胃癌 (GC),高胆固醇和其他因素调解这种效果. 需要进一步的研究来了解甲状腺功能.
科学领域:
- 遗传学和流行病学
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 胃癌 (GC) 是一个主要的全球健康问题.
- 甲状腺功能低下是影响GC风险的潜在因素.
- 甲状腺功能低下症和GC之间的因果关系和调解因素尚未得到充分理解.
研究的目的:
- 调查甲状腺功能低下症和GC风险之间的因果关系.
- 确定甲状腺功能低下症和GC之间的关联中的潜在调解者.
主要方法:
- 使用孟德尔随机化 (MR) 与来自FinnGen和MRC-IEU GWAS的遗传数据.
- 进行了单变量和多变量MR分析.
- 调整了BMI,吸烟,酒精等混因素,并分析了包括高胆固醇在内的调解因素.
主要成果:
- 在甲状腺功能低下和GC风险 (OR=0.93,P=0.003) 之间发现了显著的反向关联.
- 没有检测到反向因果关系或变性证据.
- 高胆固醇,乙型肝炎感染和糖尿病/内分泌疾病状态被确定为重要的调解因素.
结论:
- 甲状腺功能低下症似乎对抗胃癌具有保护作用.
- 这种保护作用部分由高胆固醇和其他代谢/感染因素介导.
- 这些发现强调了甲状腺功能和代谢健康在GC预防中的重要性.
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