用于评估家族性腺瘤多重症疾病严重性的内镜评分指数:系统性审查
Anna Lerman Silverman1, Hicham Bouchiba2, Arthur Aelvoet2
1Gastroenterology and Hepatology, Mayo Clinic Scottsdale, Scottsdale, United States.
目前,没有完全验证的内镜工具可用于测量家族腺瘤多重症 (FAP) 疾病的严重程度. 需要进一步开发以创建可靠的临床护理和研究工具.
科学领域:
- 胃肠病学 胃肠病学
- 医疗信息学 医疗信息学
- 临床研究 临床研究
背景情况:
- 家庭腺瘤多重症 (FAP) 缺乏标准化的内镜严重性测量.
- 针对FAP严重性的最佳内镜指数需要进行系统的评估.
研究的目的:
- 系统地审查FAP现有的内镜严重性指数的操作特性.
- 确定用于评估FAP疾病严重程度的验证工具.
主要方法:
- 在MEDLINE,EMBASE和Cochrane图书馆进行系统的文献搜索,截至2023年2月.
- 将随机对照试验 (RCT) 与内镜结果以及评估内镜指数操作性能的研究纳入FAP.
- 评价评分指数和组件项目 (多细胞数量,大小,组织学).
主要成果:
- 该审查包括了134项研究.
- 对于聚数和大小指数,发现了部分验证.
- 斯皮格尔曼分类系统对十二指甲FAP显示出良好的观察者间/观察者内部一致性;InSIGHT系统对结直肠FAP显示出实质性的观察者间可靠性.
- 其他过渡区,十二指肠和结直肠多的指数缺乏验证;新的胃多标准显示出差的一致性.
结论:
- 目前对于FAP没有完全验证的内镜疾病严重性指数.
- 开发可靠和快速响应的内镜仪器对于FAP临床护理和RCT至关重要.
- 需要有效的工具来指导治疗和评估FAP疗法的疗效.
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