利用支持性护理药物和预防性药物基因组测试的机会在患有白血病的儿科和年轻成年人中
Colleen M Sakon1, Carmina Sales2, Selsbiel Mertami3
1Indiana University Health, Indianapolis, Indiana, USA.
Pediatric hematology and oncology
|June 21, 2024
概括
儿童白血病患者经常接受药物与药物基因组指导方针 (PGx药物) 个性化剂量. 了解PGx测试可以优化治疗并改善这些年轻患者的生活质量.
科学领域:
- 药物基因组学 药物基因组学
- 儿科瘤学 儿科瘤学
- 使用药物使用药物使用.
背景情况:
- 个性化剂量在儿童白血病管理中至关重要.
- 药物基因组指南 (PGx药物) 提供了优化药物治疗的潜力.
- 关于儿童白血病患者使用PGx药物的数据有限.
研究的目的:
- 评估药物基因组指南药物 (PGx药物) 在儿科白血病中的使用情况.
- 为了确定在诊断后三年内PGx药物暴露的程度.
- 确定与PGx药物处方模式相关的因素.
主要方法:
- 对714名儿科白血病患者 (2009-2019) 的回顾性观察研究.
- 收集有关人口统计,临床特征和PGx药物暴露的数据.
- 分析了基于白血病类型,年龄和疾病复发的处方模式.
主要成果:
- 82%的患者接受了五种或更多的PGx药物.
- 丹塞,吗啡和罗醇是最常被处方的PGx药物.
- 在急性髓性白血病,未指定的白血病,青少年,成人和复发性疾病患者中观察到更高的PGx药物利用率.
结论:
- 儿童白血病患者是PGx药物的高使用者.
- 根据诊断时的年龄和疾病复发情况,PGx药物处方有很大变化.
- 建议进行预防性PGx测试,以优化药物治疗,提高生活质量,并可能降低医疗保健成本.
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