在非糖尿病成年人中,生命必需的8和胰岛素抵抗之间的关联
Shuo Pang1, Yue Wang1, Shuaifeng Sun1
1Department of Cardiology, Beijing Anzhen Hospital Capital Medical University Beijing China.
Journal of the American Heart Association
|June 21, 2024
概括
使用Life's Essential 8 (LE8) 改善心血管健康与没有糖尿病的成年人降低胰岛素抵抗 (IR) 有关. 较高的LE8分数表明心脏健康状况更好,并且与胰岛素抵抗的几率降低有关.
科学领域:
- 心血管健康 心血管健康
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 胰岛素抵抗 (IR) 是心脏代谢疾病的前体.
- 预防和管理非糖尿病人的IR对于公共卫生至关重要.
- 美国心脏协会的生命必需8 (LE8) 是心血管健康的关键指标.
研究的目的:
- 在美国非糖尿病人群中研究生命必需8 (LE8) 评分和胰岛素抵抗 (IR) 之间的关联.
- 通过整体LE8分数及其子尺度 (健康因素和健康行为) 来分析这种关系.
主要方法:
- 从国家健康和营养检查调查 (2005-2018) 中对11,246名非糖尿病成年人的横截面分析.
- 胰岛素耐药性通过胰岛素耐药性恒常模式评估 (HOMA-IR) 来评估.
- 权重后勤和线性回归模型,包括受限制的立方线,分析了LE8-IR关联.
主要成果:
- 43.2%的参与者患有胰岛素抵抗.
- 较高的LE8分数显示出与IR显著的反向关联 (OR每增加10个单位:0.57).
- 对LE8,健康行为和健康因素得分观察到非线性剂量反应关系,健康因素显示出更强的相关性.
结论:
- 生活必需品8 (LE8) 评分及其子评分与非糖尿病成年人的胰岛素抵抗相反且非线性相关.
- 通过LE8坚持促进最佳心血管健康可能是改善胰岛素抵抗的策略.
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