基于声流体的显微镜检查用于自动化和医疗中心尿液分析
Xin He1,2, Feng Ren3, Yangyang Wang1,2
1State Key Laboratory of High-performance Precision Manufacturing, Dalian University of Technology, Dalian, 116024, China. mengxiwu@dlut.edu.cn.
Lab on a chip
|June 21, 2024
概括
这项研究引入了用于尿液显微镜检查的自动声流体系统,显著提高了效率和准确性. 这种新型设备为临床尿液分析和临床检测提供了快速,经济高效的解决方案.
科学领域:
- 生物医学工程 生物医学工程
- 临床诊断 临床诊断 临床诊断
- 微流体学 微流体学
背景情况:
- 尿沉积物显微镜检查至关重要,但手动,耗时,劳动密集.
- 目前的自动化尿液分析仪器往往是庞大而昂贵的,限制了广泛采用.
- 需要有效和自动化的方法来进行微观尿液分析.
研究的目的:
- 开发基于声流体的系统,用于自动化微观尿液检查.
- 为了提高尿液分析的效率,吞吐量和自动化.
- 为临床实验室和临床检测提供一个具有成本效益和快速的解决方案.
主要方法:
- 声流体操纵与尿度的被动水力动力学机制的整合.
- 将缩尿液自动送入血细胞计室进行成像.
- 机器学习算法用于尿液沉积物的自动图像分析.
主要成果:
- 实现了高吞吐量 (1000μL min-1) 和度系数 (95.2 ± 2.1 倍).
- 红细胞 (94.6 ± 3.5%) 和白细胞 (95.1 ± 1.8%) 的检测精度.
- 使用50名志愿者的样本进行手动显微镜检查的高相关性 (0.96).
- 在3分钟内完成自动化过程.
结论:
- 开发的声流体系统为自动化尿液显微镜检查提供了一个有前途的工具.
- 有潜力显著减少临床实验室的时间和劳动力成本.
- 促进在医院和医院以外的护理点尿检测应用程序的推广.
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