破裂内动脉瘤的夜间治疗与糟糕的结果有关
Chloe Dumot1,2, Turab Gasimov1, Gokce Hatipoglu Majernik1
1Department of Neurological Surgery, University of Wisconsin-Madison, Madison , Wisconsin , USA.
Neurosurgery
|June 21, 2024
概括
在夜间治疗破裂的内动脉瘤与更糟糕的患者结局有关. 这项研究发现,与白天治疗相比,夜间治疗破裂的内动脉瘤与较差的结果有关.
科学领域:
- 神经外科 神经外科
- 血管神经学 血管神经学
- 关键护理医学 关键护理医学
背景情况:
- 破裂的内动脉瘤 (RIA) 的重新出血显著影响患者的预后.
- 治疗RIA的最佳时间是复杂的,可能会影响结果.
- 日间治疗时间对RIA结果的影响仍未得到充分探索.
研究的目的:
- 为了研究一天中的治疗时间和在破裂的内动脉瘤后患者的结果之间的关联.
- 为了比较夜间治疗的患者和白天治疗的患者的结果.
- 为了确定治疗时间是否会影响破裂内动脉瘤管理的结果.
主要方法:
- 在入院24小时内接受RIA治疗的493名患者的回顾性单中心研究.
- 通过多变量分析,使用修改的兰金尺度 (mRS) 评估结果.
- 夜间治疗定义为晚上10点至早上7点之间的程序>50%;下班时间定义为晚上7点至早上7点之间的程序>50%.
主要成果:
- 夜间治疗 (15.8%的患者) 独立地与不良结果相关 (OR:0.50 [95% CI:0.28-0.91],P = .023).
- 在白天治疗的患者中,72.0%的患者获得了有利的结局 (mRS 0-2),而在夜间治疗的患者中,这一比例为60.0%.
- 在工作时间以外的治疗 (32.5%的患者) 与不良结果没有显著的关联 (OR:0.76 [0.50-1.14],P = .18).
结论:
- 破裂内动脉瘤的夜间治疗与较差的患者结果有关.
- 需要进一步的研究来探索将治疗推迟到白天时间的好处.
- 优化治疗安排可能会改善内动脉瘤破裂患者的治疗结果.
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