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在死后精神分裂症患者大脑中的微质中发现的炎症酶蛋白表达的增加

Ryan Gober¹, Julian Dallmeier¹, David Davis^1,2

¹Brain Endowment Bank, University of Miami Miller School of Medicine, Miami, FL, United States.

Journal of neuropathology and experimental neurology

|June 21, 2024

概括

精神分裂症的神经炎症 (SCZ) 涉及微质激活和炎症体信号传递. 这项研究发现,SCZ大脑的上额叶皮层内的微质中炎症酶蛋白增加,这表明SCZ病理学中的作用.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
免疫学免疫学免疫学

背景情况:

精神分裂症 (SCZ) 是一种复杂的精神疾病,与神经炎症有关,特别是微质激活.
在SCZ病原和神经炎症中炎症组合的作用尚未完全理解.

研究的目的:

与非精神病学对照人群相比,研究SCZ患者大脑中关键炎细胞蛋白 (ASC,NLRP3,IL-18) 的表达.
确定在SCZ中表达这些炎症蛋白的特定细胞类型 (微细胞,星体细胞,寡细胞,神经元).

主要方法:

对SCZ (n=16) 和非精神病 (NP; n=13) 捐赠者的脑组织进行了免疫组织化学 (IHC) 分析.
IHC评估了含有CARD (ASC),节点状受体蛋白3 (NLRP3) 和互白素 (IL) -18.18的亡相关的斑状蛋白的表达.
在上额叶皮层 (SFC),上皮层和前带皮层分析了表达水平.

主要成果:

炎症蛋白质主要检测到SCZ和NP大脑中的微质细胞.
与NP大脑相比,SCZ大脑在SFC中显示微质细胞数量增加.
与NP对照相比,SCZ大脑的SFC中的微质中观察到ASC,NLRP3和IL-18的更高表达.

结论:

在上额叶皮层内的微质中炎症酶蛋白的表达增加与精神分裂症有关.
这些发现表明,微质中炎症酶信号的增强可能会导致SCZ的神经炎症病理.

关键词:

一些炎症一些炎症微质细胞激活活动神经炎症是一种神经炎症.在死后进行尸检.精神分裂症是一种精神分裂症.

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