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大麻二醇的新陈代谢和肝脏毒性

Si Chen¹, Yuxi Li¹, Xilin Li²

¹Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration (FDA), Jefferson, Arkansas, USA.

Journal of environmental science and health. Part C, Toxicology and carcinogenesis

|June 21, 2024

概括

Cannabidiol (CBD) 产品的使用量正在增加,但人们对未经证实的益处和安全性存在担忧. 研究表明,CBD可以对人类和动物产生不良影响,包括肝脏问题.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
肝病学肝病学是一种肝病学.

背景情况:

对非药品类大麻 (CBD) 产品的广泛公众兴趣导致了使用量的增加.
人们对CBD产品的无证实益处,缺乏质量控制以及与CBD产品相关的潜在健康风险存在担忧.
人类和动物研究都表明,CBD暴露会产生一系列的毒理效应.

研究的目的:

审查关于CBD毒理效应的人类数据和相关动物研究.
为提供与CBD相关的肝毒性,新陈代谢和药物相互作用的概述.
为了解CBD对人类健康的影响,特别是肝功能做出贡献.

主要方法:

专注于人类数据,包括临床研究和体外研究.
包括在人类数据有限的情况下进行的动物研究.
综合关于CBD毒理学和药理学的现有文献.

主要成果:

人类研究报告了诸如食欲变化,胃肠道问题,疲劳和肝酶升高等不良影响.
动物研究表明对器官体重,生殖,肝功能和免疫系统的潜在影响.
该审查强调了CBD在肝毒性和药物相互作用方面的潜力.

结论:

CBD使用与各种不良影响有关,包括潜在的肝毒性.
需要进一步的研究才能充分了解CBD的代谢途径和药物相互作用概况.
本综述总结了关于CBD毒理作用的当前知识,特别是对肝脏的影响,而没有进行风险评估.

关键词:

在这里,我们可以看到CBD CBD CBD CBD.大麻二醇 (Cannabidiol) 是一种肝脏毒性的毒性肝脏毒性代谢代谢代谢代谢毒性的毒性毒性的毒性

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